IUVSTA 15th International Vacuum Congress (IVC-15), AVS 48th International Symposium (AVS-48), 11th International Conference on Solid Surfaces (ICSS-11)
    Biomaterials Thursday Sessions
       Session BI-ThP

Paper BI-ThP1
Interactions of Dye Molecules with Poly(Propylene Imine) Dendrimer Monolayers

Thursday, November 1, 2001, 5:30 pm, Room 134/135

Session: Biomolecule and Cell Poster Session
Presenter: S. Jiang, University of Washington
Authors: S. Chen, University of Washington
L. Li, University of Washington
C. Boozer, University of Washington
S. Jiang, University of Washington
Correspondent: Click to Email
Dendrimers have been regarded as interesting candidates for applications in host-guest chemistry, such as complex drug delivery agents. A fundamental understanding of guest-host interactions in dendrimers will facilitate the effort to design new-generation chemical and biological sensors based on dendrimers. In this work, we report a systematic study of interactions between a group of dye molecules and poly(propylene imine) dendrimers (PPI) tethered to carboxyl-terminated self-assembled monolayers (SAMs). Adsorption kinetics is measured by surface plasma resonance (SPR) sensors. The fifth-generation PPI dendrimers are mainly used in this work. Our results show a strong affinity of PPI-5 to Rose Bengal or erythrosine B. The strong affinity results from well matches in charge and structure between the guest and the host molecules. In addition, the effect of various factors (e.g., dendrimer generations, charges and shapes of guest molecules, and pH values and ionic strengths of liquid solutions) on adsorption will be discussed. This is the first attempt to study the adsorption of small molecules using SPR.