IUVSTA 15th International Vacuum Congress (IVC-15), AVS 48th International Symposium (AVS-48), 11th International Conference on Solid Surfaces (ICSS-11)
    Biomaterials Wednesday Sessions
       Session BI+NS-WeA

Paper BI+NS-WeA6
Nanofabricated Lipid Bilayers Patterned on Metal Electrodes

Wednesday, October 31, 2001, 3:40 pm, Room 103

Session: Nanobiology
Presenter: R.N. Orth, Cornell University
Authors: R.N. Orth, Cornell University
I. Hafez, Cornell University
J. Kameoka, Cornell University
M. Lindau, Cornell University
H.G. Craighead, Cornell University
Correspondent: Click to Email
Lipid molecules were immobilized on the surface of photolithographically patterned chromium and titanium. Large unilamellar lipid vesicles were found to bind on the native oxide surface of patterned support metals. Metal evaporation and resist liftoff techniques were used to pattern metal on a hydrophobic polymer surface. Lipids bound on solid substrates provide a biological interface for impedance measuring electrodes to detect bound cells or biomaterial. This patterning technique provides means to specifically bind lipids and conjugated biomaterials (polyethelene glycol (PEG), biotin, fluorescence dyes, and DNA oligimers) to the electrode surface. This technique may be applied to patterning biomaterial on metal inside thermally bonded microfluidic channels, to form titanium coated biomedical implants, and to create robust lipid-conjugated electrodes for biosensor applications.