IUVSTA 15th International Vacuum Congress (IVC-15), AVS 48th International Symposium (AVS-48), 11th International Conference on Solid Surfaces (ICSS-11)
    Biomaterials Tuesday Sessions
       Session BI+MM-TuM

Paper BI+MM-TuM3
Micropatterns of Biomolecules on Silicon Hydride Surfaces

Tuesday, October 30, 2001, 9:00 am, Room 102

Session: Biomems & Microdevices
Presenter: M. Grunze, University of Heidelberg, Germany
Authors: J. Pipper, University of Heidelberg, Germany
U. Fritz, University of Heidelberg, Germany
R. Dahint, University of Heidelberg, Germany
M. Grunze, University of Heidelberg, Germany
Correspondent: Click to Email
Biochips yield a high potential for technological progress in the fields of diagnostics, drug discovery and nanotechnology. They are usually fabricated by photo- and softlithographic methods, various printing techniques or the use of micro electrodes. Common substrate materials are glass-, silicon oxide- and gold surfaces. A powerful alternative to these approaches is the photochemically initiated attachment of terminally functionalized 1-alkenes onto silicon hydride surfaces accompanied by Si-C single bond formation. Although the high potential use of silicon microstructures for biosensing applications has been postulated for years, it has not been exploited yet due to a lack of functional groups suitable for the coupling of biological species. Problems in surface derivatization occur as a result of unwanted parallel chemical reactions and a possible fragmentation of the organic compounds during illumination. This dilemma has now been overcome by temporarily masking the chemical functionalities with non-photolabile protective groups. The paper reports on the spatially resolved, photochemical modification of planar and porous silicon hydride surfaces for the immobilization of DNA, proteins and cells. In combination with photoactive compounds, the method of light induced surface derivatization can also be transferred to organic materials.