The usefulness of patterned surfaces, which specifically bind antagonists has been recognized for a wide variety of biomedical applications ranging from drug screening to tissue engineering. Current technologies for creating patterned surfaces suffer from many drawbacks. For optimized results, technologies that are flexible, use a large number of different proteins, high-throughput and inexpensive are warranted. Ink jet technology has shown promise in meeting these criteria and commercial systems are being developed. High throughput and quantitative assaying of the patterns is equally challenging. For example, in early cancer detection, it is desirable to detect a few abnormal cells within millions of normal cells. It is unlikely that PCR based techniques or gene chips will be economically feasible tools for early detection since most of the cost will be associated with analyzing normal DNA. Economical high-throughput screening and concentration technologies may be able to discriminate and select abnormal cells for further analysis. We developed a piezo driven protein and cell printer in our laboratory, able to simultaneously deposit picoliter drops of cell or protein solutions out of nine nozzles. The printer can deliver a single cell per drop to a surface with submicron resolution. Furthermore, it is equipped with a robotic arm and conveyer belt allowing for truly high-throughput printing. Examples of its use including for anti angiogenesis drug screening will be presented. Quantitative assaying is done using a cell scanner. The cell scanner has a resolution of less than 2 µ, is fully computer controlled, high-throughput and an economically attractive when compared to epifluorescent microscopes. Results will be presented with fluorescently labeled cells demonstrating the potential of the cell scanner for high-throughput discrimination and selection of prostate cancer cells.