IR transmitting chalcogenide glasses and fibers are being developed at the Naval Research Laboratory for numerous military, commercial and biomedical applications in the infrared region. Significant progress has been made in the areas of chemical and glass purification, glass fabrication and fiberization technology. Consequently, long lengths of optical fibers have been fabricated that possess low loss, high strength and high threshold to laser damage. The fibers are being developed for, and implemented in, infrared countermeasure systems, threat warning systems and fiber optic based chemical sensor systems for facility clean up and environmental monitoring as well as biomedical tissue diagnostics. The fibers have also been used in a scanning near field infrared microscope (SNIM) to demonstrate an optical resolution of 100 nm and topographic resolution of 20 nm. The ability to dope these materials with rare earth ions has led to bright sources in the IR beyond 2 um which are useful for characterizing missile seekers and focal plane array detectors. In addition, these low phonon energy glasses are excellent hosts for rare earth ions for making potential lasers and amplifiers. We will present our latest results regarding fabrication of the fibers, fiber properties and their applications.