AVS 47th International Symposium
    Biomaterial Interfaces Monday Sessions
       Session BI+SS-MoM

Paper BI+SS-MoM5
New Methods for Patterning Fluid Lipid Bilayer Membranes on Solid Supports

Monday, October 2, 2000, 9:40 am, Room 202

Session: Biological Surface Science
Presenter: J.S. Hovis, Stanford University
Authors: J.S. Hovis, Stanford University
S.G. Boxer, Stanford University
Correspondent: Click to Email
Two new methods are introduced for patterning fluid lipid bilayer membranes on solid supports. These methods, called blotting and stamping, rely on the observation that supported lipid bilayers exhibit self-limiting lateral expansion. The consequence is that it is possible to pattern these fluid surfaces without modifying the underlying substrate. Together these methods constitute a simple and powerful approach for preparing patterned fluid lipid bilayers in nearly any geometry. One important application of these methods is the ability to create composition arrays of lipids and membrane associated proteins. These arrays allow the opportunity to study lipid-lipid, lipid-protein, and/or protein-protein interactions in a parallel fashion. Information gained about these important biological interactions will be highlighted.