AVS 47th International Symposium
    Biomaterial Interfaces Monday Sessions
       Session BI+SS-MoM

Paper BI+SS-MoM2
Formation and Characterization of Stabilized Supported Phospholipid Bilayers

Monday, October 2, 2000, 8:40 am, Room 202

Session: Biological Surface Science
Presenter: S. Saavedra, University of Arizona
Authors: S. Saavedra, University of Arizona
E. Ross, University of Arizona
J. Conboy, University of Arizona
S. Liu, University of Arizona
D.F. O'Brien, University of Arizona
Correspondent: Click to Email
The utility of phospholipid bilayers as non-fouling coatings in molecular device technologies is hampered by the chemical and mechanical instability of these structures relative to (for example) alkylsiloxane self-assembled monolayers. Towards the use of lipid bilayers in applications such as biosensing, we have investigated two-dimensional polymerization as a strategy to stabilize planar supported lipid bilayers. UV-induced and redox-initiated polymerization have been used to prepare air-stable bilayers from phosphatidylcholine monomers containing sorbyl moieties in the acyl chains. Preparation of these structures using Langmuir-Blodgett-Kuhn and vesicle fusion techniques, and characterization of their physical and chemical properties, including nonspecific protein adsorption behavior, will be described.