Scientists and engineers have anticipated the potential benefits of integrating engineered devices to living systems at the molecular level for many years. Hybrid systems can potentially possess many of the essential properties of life such as the abilities to "intelligently" self-assemble, repair, and evolve. We will present the results of our efforts to incorporate biological energy transduction processes and cell signaling pathways into engineered nanofabricated devices. In particular, we will illustrate our strategy for fueling, controlling and integrating a F1-ATPase biomolecular motor with a NEMS to create an engineered hybrid device. Included in the presentation will be the initial results of our efforts to develop and demonstrate an integrated F1-ATPase powered NEMS device that is fueled by light-driven ATP production. ATP is synthesized from light using artificial liposomes comprised of reconstituted FoF1-ATP synthase and bacteriorhodopsin. Subsequently, the ATP provides energy to power a recombinant, thermostable F1-ATPase biomolecular motor that is coupled to a NEMS device. We will also present our technique for integrating nanomechanical structures to biomolecular motors with a precision d 40 nm. This work capitalizes on a core feature of living systems: the capability of transforming diverse sources of energy into a generic energy currency that can be universally used. The integration of a synthetic photosynthetic system with NEMS establishes a new mechanism for fueling the next generation of nanoelectromechanical devices. Light is used to produce ATP from ADP and P, the ATP is used by the F1-ATPase biomolecular motor to produce work with ADP and P as waste products. Ultimately, we anticipate that this chemically closed system will be used to pump fluids, open and close microvalves, provide locomotion, generate electricity, and make way for "Smart Dust" applications such as long-lived microscopic intelligence and environmental sensors.