AVS 47th International Symposium
    Biomaterial Interfaces Monday Sessions
       Session BI+MC-MoA

Paper BI+MC-MoA3
Electrochemical SPR for Biomaterial Applications

Monday, October 2, 2000, 2:40 pm, Room 202

Session: Characterization of Biomaterial Interfaces
Presenter: R.M. Georgiadis, Boston University
Authors: R.M. Georgiadis, Boston University
R.J. Heaton, Boston University
Correspondent: Click to Email
Electrochemical SPR is the combination two powerful surface specific techniques which together provide the basis for many surface modification and detection schemes with new applications to biomaterial interfaces. Although the general effect of an applied electrochemical potential on the surface plasmon resonance response from a simple metal surface is well known, the response from more complex interfaces has not been studied in detail. Yet, such studies are crucial for many applications such as quantifying binding at interfaces in the presence of an applied electrochemical field. We show that very useful information can be obtained directly from the potential dependent SPR optical data: the potential of zero charge can be determined in the presence or absence of immobilized organic or biomaterial films and the specific adsorption of anions can also be distinguished. We report results for a series of modified interfaces including self assembled monolayer films and for thiol bound DNA oligomer films in various electrolytes.