AVS 46th International Symposium
    Biomaterial Interfaces Group Wednesday Sessions
       Session BI-WeP

Paper BI-WeP5
Do Oligoethyleneglycol Terminated Alkanthiols Induce Complement Activation?

Wednesday, October 27, 1999, 5:30 pm, Room 4C

Session: Poster Session
Presenter: J.M. Benesch, Linköping University, Sweden
Authors: J.M. Benesch, Linköping University, Sweden
S. Svedhem, Linköping University, Sweden
S. Svensson, Linköping University, Sweden
P. Tengvall, Linköping University, Sweden
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oligoethyleneglycol terminated alkanthiols with varying length of the ethylenglycol repeats were self assembled on gold surfaces. In Situ antibody ellipsometry techniques were used to study protein adsorption when the surfaces are incubated in serum or plasma. The results so indicate depositions of serum and also deposits of complement factors. This indicates that oligoethyleneglycol surfaces are not serum and plasma resistent. This behavior is dependent on the presence of calcium and the number of repeats in the ethylenglycol chain.