AVS 46th International Symposium
    Biomaterial Interfaces Group Wednesday Sessions
       Session BI-WeP

Paper BI-WeP11
Time-of-Flight SIMS Analysis of Micropatterned Biomaterial Arrays

Wednesday, October 27, 1999, 5:30 pm, Room 4C

Session: Poster Session
Presenter: S.L. Golledge, University of Washington
Authors: S.L. Golledge, University of Washington
M.D. Garrison, University of Washington
B.D. Ratner, University of Washington
Correspondent: Click to Email
Micropatterned arrays of thin films, self-assembled monolayers and biomolecules are a critical enabling technology for the development of miniaturized biosensors and next generation biomaterials. Accurate characterization of the locally defined surface functional states is therefore crucial to the successful implementation of these novel approaches to surface engineering. We employed Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS), in both spectroscopic (static) and imaging modes to define and identify the spatial presentation of (1) bioactive polymeric materials prepared via radio-frequency glow-discharge (RFGD), (2) non-fouling organic thin-films patterned through microcontact printing (uCP), and (3) direct uCP matrix proteins important in biological wound healing. TOF-SIMS allowed characterization of both the bioactive species and the engineered reference regions, in addition to assuring that unwanted contaminant species were not present. Future prospects for TOF-SIMS analysis of micropatterned arrays will be proposed.