AVS 46th International Symposium
    Biomaterial Interfaces Group Wednesday Sessions
       Session BI-WeM

Paper BI-WeM2
Reactions of Biological Cells to Nanostructures

Wednesday, October 27, 1999, 8:40 am, Room 613/614

Session: Cell Solid-Surface Interactions
Presenter: A.S.G. Curtis, University of Glasgow, Scotland
Authors: A.S.G. Curtis, University of Glasgow, Scotland
C.D.W. Wilkinson, University of Glasgow, Scotland
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The reactions of biological cells to nanostructured polymer and silica surfaces will be described. The surfaces have been prepared in a variety of materials using E-beam methods, colloidal resists and replication by embossing. The reactios include changes in adhesion and cytoskeletal organisation. The effects of topography in the ranges 20-100nm greatest plan dimension, 50-200nm repeat and 10-100nm height will be described. The degree to which the cells conform to these surfaces will be reported with details of the closeness of approach of the cells to the surfaces. The question of whether the reactions are to topography, chemistry or surface disorder at boundaries will be discussed.