AVS 46th International Symposium
    Biomaterial Interfaces Group Tuesday Sessions
       Session BI-TuP

Paper BI-TuP14
Microcontact Printing of Protein Patterns to Direct Cellular Response

Tuesday, October 26, 1999, 5:30 pm, Room 4C

Session: Poster Session
Presenter: T.C. McDevitt, University of Washington
Authors: T.C. McDevitt, University of Washington
M.D. Garrison, University of Washington
T.R. Kyriakides, University of Washington
M. Scatena, University of Washington
P. Bornstein, University of Washington
C.M. Giachelli, University of Washington
P.S. Stayton, University of Washington
Correspondent: Click to Email
In order to control the cellular response at a biomaterials interface, we are applying micropatterning techniques to spatially arrange extracellular matrix (ECM) ligands on surfaces. Cell function has previously been related to cell shape and cytoskeletal architecture, thus we are investigating how microcontact printing of proteins can be used to modulate these parameters. Various combinations of ECM proteins can be patterned to create heterogeneous, ordered surfaces that selectively promote cell adhesion, spreading, and intracellular signaling events. Designated adhesive and non-adhesive regions are dictated by the choice of particular ECM proteins which possess these characteristics and cell attachment is confined by the features of the micropatterning. Our aim is to use micropatterning as a tool to recreate an ordered, complex surface that more accurately resembles the true ECM, stimulates a specific and desirable cellular response, and thus induces a more favorable interaction with the biomaterial.