AVS 46th International Symposium
    Biomaterial Interfaces Group Thursday Sessions
       Session BI-ThM

Paper BI-ThM11
Peptide Functionalized Titanium Alloy Surfaces for Orthopedic and Dental Materials

Thursday, October 28, 1999, 11:40 am, Room 613/614

Session: Biomineralization
Presenter: F.A. Akin, University of Illinois, Chicago
Authors: F.A. Akin, University of Illinois, Chicago
L. Hanley, University of Illinois, Chicago
H. Zreiqat, University of New South Wales, Australia
C.R. Howlett, University of New South Wales, Australia
Correspondent: Click to Email
Surface modification to a biomaterial may improve long term survival of prosthetic devices. The modulation of bone behavior was examined by surface chemical modification of titanium alloy (Ti-6Al-4V) using peptides. RGDSC (arginine-glycine-aspartate-serine-cysteine) was covalently bound to the Ti-6Al-4V surface by 3-aminopropyltriethoxysilane. Surface characterization of amine-, cysteine-, and RGDSC-terminated Ti-6Al-4V was determined using x-ray photoelectron spectroscopy, roughness assesment, and scanning electron microscopy. All elemental peaks as well as the valence band are employed in the x-ray photoelectron spectral analysis of RGDSC on Ti6Al4V. The S(2p) peak was used to determine the atomic percentage of S on the surface, providing information on the peptide surface density. The valence band of the XPS also showed significant differences between the three surfaces. The attachment and proliferation of human bone-derived cell (HBDC) to the amine-, cysteine-, and RGDSC-terminated Ti-6Al-4V were examined using colorimetric and immunohistochemical assays.