AVS 46th International Symposium
    Biomaterial Interfaces Group Thursday Sessions
       Session BI-ThM

Paper BI-ThM1
Nucleation and Growth of Calcium Phosphate on Self-Assembled Monolayers

Thursday, October 28, 1999, 8:20 am, Room 613/614

Session: Biomineralization
Presenter: C.C. Chusuei, Texas A&M University
Authors: C.C. Chusuei, Texas A&M University
B.J. Tarasevich, Pacific Northwest National Laboratory
D.L. Allara, Pennsylvania State University
M.J. Van Stipdonk, Texas A&M University
E.A. Schweikert, Texas A&M University
D.W. Goodman, Texas A&M University
Correspondent: Click to Email
Calcium phosphate (CP) was adsorbed onto 16-carbon chain length self-assembled monolayers (SAMs) with various terminated functional groups from solution simulating ionic conditions found in blood plasma at the bone growth region at various exposure times to observe the onset of nucleation growth. X-ray photoelectron spectroscopy (XPS) was used to quantitate nucleation and growth of CP on the surface and compared with ellipsometric measurements. Secondary ion mass spectrometry (SIMS) was used for speciation, monitoring transformation from amorphous phases to hydroxyapatite and comparing them to standardized CP powders.@footnote 1@ Accelerated nucleation and growth of CP on anionically charged SAMs terminal functional groups, -COOH and -SO@sub 4@H, was readily observed at 310 K (consistent with physiological conditions) relative to room temperature (298 K). No growth was observed on the -CH@sub 3@ terminated SAMs. @FootnoteText@ @footnote 1@ Chusuei, C. C.; Van Stipdonk, M. J.; Justes, D. R.; Schweikert, E. A.; Goodman, D. W. Anal. Chem. 1999, 71, 149-153.