AVS 46th International Symposium
    Biomaterial Interfaces Group Monday Sessions
       Session BI-MoM

Invited Paper BI-MoM3
Gene Engineering for Biosensor-Biology Interface

Monday, October 25, 1999, 9:00 am, Room 613/614

Session: Biosensor-Biology Interface
Presenter: M. Aizawa, Tokyo Institute of Technology, Japan
Authors: M. Aizawa, Tokyo Institute of Technology, Japan
E. Kobatake, Tokyo Institute of Technology, Japan
Y. Yanagida, Tokyo Institute of Technology, Japan
T. Haruyama, Tokyo Institute of Technology, Japan
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Biosensor technology has made a remarkable progress in these three decades, which may be characterized by unique integration of immobilization and measurement technologies in the first generation, effective employment of advanced technologies such as microelectronics in the second generation and its own development based on generic technology in the third generation. Up to the second generation, the progress of biosensor technology has been realized by adopting the related technologies. It should be regretful, however, that no biosensor material, for instance, has been designed or synthesized for its own purpose. Much effort has been devoted to adopting a native biomolecule to fit a biosensor. It is not until the third generation that biosensor material is designed for its own purpose on the basis of advanced technology. For the progress of biosensor technology, sensing material design technology should be advanced in harmonization with process technology as well as system technology. As far as sensing material design technology, we should concentrate on designing biosensing materials on the basis of gene engineering for the development of the third generation of biosensors. Gene engineering may fall in three categories of engineering including gene designing of proteins, designing of gene expression process and gene diagnosis. In this paper, both gene designing of proteins and designing of gene expression processes for biosensing are described with focusing on our current achievement.