AVS 46th International Symposium
    Biomaterial Interfaces Group Friday Sessions
       Session BI-FrM

Paper BI-FrM9
Planar Polymerized Phospholipid Bilayers as Biocompatible Substrates

Friday, October 29, 1999, 11:00 am, Room 613/614

Session: Interface, Properties, and Modification
Presenter: J.C. Conboy, University of Arizona
Authors: J.C. Conboy, University of Arizona
S. Liu, University of Arizona
D.F. O'Brien, University of Arizona
S.S. Saavedra, University of Arizona
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There is considerable interest in finding a surface that is resistant toward non-specific protein adsorption and is chemically and mechanically stable. Hydrophilic surfaces, such as those of a zwitterionic phospholipid bilayer, are inherently biocompatible with intrinsically low nonspecific protein interactions. However, planar supported lipid bilayers are only weakly associated, making their stability less then desirable from an applications standpoint. Toward the goal of producing a stable and intrinsically biocompatible substrate, we endeavored to produce planar polymerized analogs of phospholipid bilayers. A photosensitization method was used to polymerize the lipid bilayers in aqueous media. The rate of polymerization and subsequent structural changes in the lipid film were examined by in-situ Raman spectroscopy. The stability of the lipid films was determined before and after in-situ polymerization by a number of methods. Their application as substrates for optical biosensors will also be discussed.