AVS 45th International Symposium
    Biomaterial Interfaces Group Monday Sessions
       Session BI-MoP

Paper BI-MoP2
Curvature-Induced Domain Formation in Lipid Bilayer Membranes

Monday, November 2, 1998, 5:30 pm, Room Hall A

Session: Biomaterial Interfaces Poster Session
Presenter: C.D. Keating, Pennsylvania State University
Authors: C.D. Keating, Pennsylvania State University
T.G. D'Onofrio, Pennsylvania State University
M.J. Natan, Pennsylvania State University
P.S. Weiss, Pennsylvania State University
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A number of studies have suggested the importance of domain formation in biological membranes. We describe recent results concerning the effect of lipid bilayer lateral heterogeneity on model membrane function in single unilamellar vesicles. Initial work has focused on preparation and imaging of lipid membranes of various curvatures, and manipulation of these membranes in flowing solution by optical trapping. Several methods have been applied to alter liposome morphology, from encapsulation of materials (both biological and nonbiological) to stretching vesicles using multiple optical traps. Fluorescence microscopic data on lateral domains as a function of membrane curvature will be discussed.