Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2018)
    Nanomaterials Tuesday Sessions
       Session NM-TuP

Paper NM-TuP11
Efficient Antiviral Delivery Polymersomes by Optimization of Surface Density of Cell-targeting Groups for Virus Treatment

Tuesday, December 4, 2018, 4:00 pm, Room Naupaka Salon 1-3

Session: Nanomaterials Poster Session I
Presenter: Chaewon Park, Yonsei University, Republic of Korea
Authors: C. Park, Yonsei University, Republic of Korea
H. Chun, Yonsei University, Republic of Korea
M. Yeom, Korea University, Republic of Korea
H.-O. Kim, Korea University, Republic of Korea
J.-W. Lim, Yonsei University, Republic of Korea
W. Na, Korea University, Republic of Korea
G. Park, Yonsei University, Republic of Korea
A. Kang, Korea University, Republic of Korea
D. Yun, Yonsei University, Republic of Korea
J. Kim, Yonsei University, Republic of Korea
D. Song, Korea University, Republic of Korea
S. Haam, Yonsei University, Republic of Korea
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Influenza A virus (IAV), which causes one of the most contagious diseases is a global health concern, and is responsible for seasonal epidemics and pandemics. Despite laudable advances in antiviral agents and drugs, the vast majority of them have shown limited efficacy due to non-specificity and low viability in physiological or endosomal environment, especially in the case of intracellular drug. A nano platform, consisting of phenylboronic acid (PBA) pendant group polymer which has sialic acid-targeting property, gained greater access to the intracellular space transporting antivirals within the host cell. Amphiphilic copolymers made of pPhe-b-mPEG-PBA formed polymersomes which encapsulated hydrophilic antiviral agents in the core and hydrophobic drugs in the exterior layer. Combination of antiviral drug delivery using amphiphilic nanocarrier and cell-targeting functional group gives a better chance to improve transfection and intracellular distribution efficiency of therapeutic substances.