| Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2018) | |
| Biomaterial Surfaces & Interfaces | Tuesday Sessions |
| Session BI-TuP |
| Session: | Biomaterial Interfaces Poster Session |
| Presenter: | Andreas Skallberg, Linköping University, Sweden |
| Authors: | C. Brommesson, Linköping University, Sweden N. Abrikossova, Linköping University, Sweden P. Eriksson, Linköping University, Sweden Z. Hu, Linköping University, Sweden K. Uvdal, Linköping University, Sweden A. Skallberg, Linköping University, Sweden |
| Correspondent: | Click to Email |
The use of nanomaterials in biomedical applications create a large need for studies elucidating potential harmful effects of the materials in living systems. Nanomaterials specifically aimed for in vivo applications are sure to encounter all components of blood, directly or indirectly, and increased knowledge of underlying mechanisms at the blood cell-nano interface will be valuable in the further development of these materials.
We have specifically investigated blood platelet and neutrophil granulocyte interaction with several types on nanoparticles. These blood cells are rapidly responding, and potent cells involved the immune response and following inflammatory processes. Using well-defined and characterized NPs we have focused on clarifying the induced functional cellular responses, interaction mechanisms and involved signaling pathways. Our results demonstrate uptake of polymeric (Pdots) and Cerium/Gadolinium based NPs in neutrophils and show that both active and passive uptake processes contribute to the internalization of these particles. In connection, cellular mechanisms underlying our previously described antioxidative properties of cerium containing NPs1 are further investigated and identified. Nanoparticle induced platelet aggregation and release of inflammatory mediators is also shown herein to be valuable for evaluating NP- blood compatibility.
1 P. Eriksson el al. Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement. Scientific Reports 2018; 8:6999