| Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2018) | |
| Biomaterial Surfaces & Interfaces | Monday Sessions |
| Session BI-MoM |
| Session: | 35 Years of NESAC/BIO I |
| Presenter: | Daniel Graham, University of Washington |
| Authors: | D.J. Graham, University of Washington L.J. Gamble, University of Washington D. Castner, University of Washington |
| Correspondent: | Click to Email |
ToF-SIMS data is complicated. Even a single spectrum can contain hundreds if not thousands of peaks. Each peak corresponds to a unique element, fragment or molecule from the surface analyzed. The relative intensity of these peaks can encode information about the chemistry, structure and composition of the surface. With modern ToF-SIMS instrumentation it is straight forward to collect multiple spectra across multiple samples resulting in large, complex data sets. To further add to the scale of the data one can also produce 2D and 3D ToF-SIMS images which can consist of millions of spectra and fill gigabytes of storage space. Since 1992 NESAC/BIO has lead the way in developing innovative tools that enable digestion of this smorgasbord of ToF-SIMS data. This included some of the first papers published applying multivariate analysis (MVA) methods to ToF-SIMS data. This effort has lead to the creation of the NBToolbox which contains a set of advanced tools to process and display ToF-SIMS spectra and images. Though the ToF-SIMS community is relatively small, the NBToolbox has over 300 users across 39 countries on 6 continents. It is regularly used in research presented in publications and presentations around the world. In this presentation I will highlight the developments spearheaded through the years by NESAC/BIO in ToF-SIMS data processing from spectra to 3D imaging. Examples will be presented from the early beginnings of “simple” controlled systems to current work with complex tissue samples in 2D and 3D.