Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2016)
    Biomaterial Surfaces & Interfaces Wednesday Sessions
       Session BI-WeM

Paper BI-WeM10
Exploring Protein and Mesoporous Silica Nanoparticle Interactions

Wednesday, December 14, 2016, 11:00 am, Room Milo

Session: Biomolecule/Material Interactions
Presenter: Brian Trewyn, Colorado School of Mines, USA
Authors: B. Trewyn, Colorado School of Mines, USA
M. Moyer, Colorado School of Mines, USA
Correspondent: Click to Email
Tandem and cascade reactions have the potential to save time and resources, advantages not frequently observed in individual, stepwise reactions. The versatile, ordered pore structure of mesoporous silica nanoparticle (MSN) materials is an ideal support for multiple, active catalysts that potentially have orthogonal optimal conditions. Herein, we will demonstrate that enzymes covalently tethered to MSN can be paired to inorganic species to catalyze multistep reactions. Additionally, MSN can be used to entrap large, multisubunit proteins as individual subunit monomers. Upon release, we will demonstrate that the subunits reassociate to form biochemically active proteins.