Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2016)
    Biomaterial Surfaces & Interfaces Tuesday Sessions
       Session BI-TuP

Paper BI-TuP9
Hydrophilic Itaconic Acid Based Material Coating on Silicone Implants Surface for Inhibition of Capsular Contracture

Tuesday, December 13, 2016, 4:00 pm, Room Mauka

Session: Biomaterial Surfaces & Interfaces Poster Session
Presenter: Hansoo Park, Chung Ang University
Authors: M. Birajdar, Chung Ang University
YB. Choy, Seoul National University, Korea
S. Lee, CHA
H. Park, Chung Ang University
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The capsular contracture has been a serious problem for silicone implants, leading to surgical removal or surgical replacement. Recently, the silicone implants were modified with textured surface and coated with biomimetic materials to overcome this complication. In this work, we modified the surface of silicone implants with highly hydrophilic itaconic acid (IA) based materials having antibacterial properties and investigated their effect on inhibition of capsular contracture. Various formulation including IA alone, Oligo IA, IA-gelatin polymers, gelatin particles containing IA were tested. The results confirmed the coating of silicone surface with thin layers of IA based materials with concentration dependent manner. It was also found that the contact angle was decreased in all groups, confirming the increase in hydrophilicity. In vitro cell adhesion and protein adsorption were also tested on the modified silicone and compared to the unmodified silicone. These surface modification of IA based materials could be used as a potential alternative to inhibit the formation of capsular contracture.