| Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2016) | |
| Biomaterial Surfaces & Interfaces | Tuesday Sessions |
| Session BI-TuP |
| Session: | Biomaterial Surfaces & Interfaces Poster Session |
| Presenter: | Fu-Der Mai, Taipei Medical University, Taiwan, Republic of China |
| Authors: | C.C. Yu, Vanung University, Taiwan, Republic of China W.J. Lin, Central Police University, Taiwan, Republic of China S.M. Wang, Central Police University, Taiwan, Republic of China F.D. Mai, Taipei Medical University, Taiwan, Republic of China |
| Correspondent: | Click to Email |
Due to a dramatic change in both the lifestyle and eating habits, a steady increase in risk of gastrointestinal diseases every year. Early detections and treatments can reduce the mortality caused by gastrointestinal diseases. Fecal occult blood (FOB) is a small amount of blood in the stool which is invisible to human eye. If blood is detected in FOB, the cause may be gastrointestinal disorders, such as colorectal polyps, colorectal cancer and, etc. Fecal occult blood test (FOBT) is a rapid and non-invasiveness method for early diagnostics about gastrointestinal diseases. In this study, we present an alternative method for FOBT other than the traditional methods by using the time-of-flight secondary ion mass spectrometry (TOF-SIMS). TOF-SIMS can analyzes the molecular composition of the sample surface with a simple pre-treatment or even without any pre-treatment. Furthermore this method can avoid the potential pitfalls found in the traditional FOBT, such as the false positive results due to the interfere of food and drugs in the chemical method and the false negative responses due to the hemoglobin degradation during the storage in the immunization method. Preliminary results shown that there are significant differences at m / z = 86 and m / z = 184 for the stool samples with FOB. Currently we test different pre-treatments to achieve consistency and accuracy of the experimental results.