Invited Paper BI-TuM2
ToF-SIMS Imaging for Nano-Bio Applications
Tuesday, December 13, 2016, 8:20 am, Room Milo
Although the collisional cascade process in ToF-SIMS is unable to produce secondary ions with a molecular weight of over m/z 2,000 without the use of noble metals or special matrixes, time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging is a powerful technique for producing chemical images of small biomolecules (ex. metabolites, lipids, peptides) “as received” because of its high molecular specificity, high surface sensitivity, and submicron spatial resolution. For large biomolecules, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been used for molecular identification of proteins in the discovery of disease-related biomarkers as a key platform technique in proteomics.
For this talk, I will show that the label-free ToF-SIMS imaging technique can be a platform technology for characterization of organic-conjugated nanoparticles, disease diagnosis and drug screening. In addition, I will discuss the potential capability of Ar-cluster SIMS to study omics, particularly proteomics and lipidomics for brain studies.