| Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2016) | |
| Biomaterial Surfaces & Interfaces | Tuesday Sessions |
| Session BI-TuM |
| Session: | Bioimaging & Bionanotechnology |
| Presenter: | Ja-Hyoung Ryu, Ulsan National Institute of Science and Technology, Republic of Korea |
| Correspondent: | Click to Email |
Nanoscopic delivery vehicles capable of encapsulating drug molecules and releasing them in response to
external stimuli are of great interest due to implications in therapeutic applications. Sequential drug delivery with dual
stimulus responsive nanotherapeutics is highly desirable for disease specific treatment in cancer therapy with
minimized adverse effects. In addition to this, on-demand therapy received considerable attention among the
treatment techniques. Herein, we present the design of robust, new and simple pH dependent charge conversional
non-covalent polymer gatekeepers technique by preparing the hydrophilic and hydrophobic drug loading at high
capacity and improved encapsulation stability in hollow mesoporous container for target specific cellular uptake for
cancer treatment. The di-isopropyl methacrylate functionalized monomer facilitates the fast cellular uptake at acidic
environment of cancer cells and allows the on-demand release of hydrophillic drug at acidic pH of endosomes upon
protonation. Pyridine disulfide facilitates the strong encapsulation of loaded cargo upon crosslinking by thiol-disulfide
exchange and releases the cargo upon exposure with increased intracellular glutathione concentration. The codelivery
of the multi-drugs in single carrier enables a synergistic chemotherapeutic effect. Based on this new design, a
wide range of sequential and synergistic therapy can be achieved to satisfy varied clinical requirements.