| Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2016) | |
| Biomaterial Surfaces & Interfaces | Tuesday Sessions |
| Session BI-TuE |
| Session: | Medical Applications |
| Presenter: | Jinn P. Chu, National Taiwan University of Science and Technology, Taiwan, Republic of China |
| Authors: | C. Yu, National Taiwan University of Science and Technology, Taiwan, Republic of China Y. Tanatsugu, National Taiwan University of Science and Technology, Taiwan, Republic of China C. Li, National Taiwan University of Science and Technology, Taiwan, Republic of China C. Lee, National Taiwan University of Science and Technology, Taiwan, Republic of China J. Chu, National Taiwan University of Science and Technology, Taiwan, Republic of China M. Chen, Mackay Memorial Hospital Tamsui Campus, Taiwan, Republic of China S. Chang, Mackay Memorial Hospital Tamsui Campus, Taiwan, Republic of China |
| Correspondent: | Click to Email |
Thin film metallic glasses (TFMGs) possess exceptional mechanical properties adopted from its bulk form such as high strength, large elastic limits, and excellent corrosion and wear resistances owing to their amorphous structure. In addition, the smooth surface, due to the grain boundary-free structure, and low surface free energy of TFMGs in certain compositions can be achieved and leads to the relatively high hydrophobicity and the low coefficient of friction.
In our studies, TFMG coatings are deposited using RF magnetron sputtering for various biomedical applications, including the property enhancements of dermatome blades and syringe needles, adhesion resistance of platelet, as well as the suppression of cancer cell attachments. The TFMG-coated dermatome blades show great enhancements in sharpness and durability, compared with those of the bare one. For the syringe needle, significant reductions in insertion and retraction forces for TFMG-coated needle are found due to the non-sticky property and relatively low coefficient of friction. For thrombosis reduction, less platelet aggregations are observed on the TFMG than that of on the bare glass in platelets adhesion test, suggesting TFMG-coated catheters is potentially useful to be placed into vessels for long periods of time with reduced numbers of the aggregation of blood platelets. For cancer cell attachment suppressions, TFMG exhibits the least cancer cell attachment among other control groups. Thus, anti-proliferation and anti-metastasis of medical tools can be achieved with TFMG coating.