| Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2016) | |
| Biomaterial Surfaces & Interfaces | Monday Sessions |
| Session BI-MoE |
| Session: | Soft Surface & Biofunctional Coatings |
| Presenter: | Razieh Khalifehzadeh, University of Washington, USA |
| Authors: | R. Khalifehzadeh, University of Washington, USA B.D. Ratner, University of Washington, USA |
| Correspondent: | Click to Email |
Bioresorbable stents are an emerging, novel treatment for improving long-term stent outcomes. Rigid metallic stents are associated with failure over time partly due to their permanent presence in vessel walls inhibiting physiologic vasomotion and stimulating neointimal hyperplasia. Among various polymers, poly(lactic acid) (PLA) has been extensively used for making bioresorbable stents. PLA undergoes degradation through hydrolysis of ester bonds. The degradation products are lactic acid and oligomers that later metabolize into CO2 and water.
Despite the various long-term advantages of bioresorbable stents, their reported thrombosis is higher than metallic stents. In an attempt to improve blood compatibility of PLA, we used radio frequency glow discharge (RFGD) to modify the surface of this polymer with perfluoro compound. Fluoropolymers have been shown to lower thrombogenicity and platelet reactivity, and are extensively used in blood contacting materials.
Here, we have developed a process to coat the surface of PLA with perfluoro compound. Electron spectroscopy for chemical analysis (ESCA) was used to analyze the surface composition of these polymers. In addition, contact angle measurements, cell cytotoxicity, and degradation profile were evaluated.
Finally, we will assess the blood compatibility of these modified surfaces by using radiolabeled blood plasma proteins (albumin and fibrinogen) adsorbed onto their surface. The adsorption of plasma proteins is the central event in the biofouling of blood-contacting surfaces, which occurs immediately upon exposure of blood to biomaterial. We hypothesiz that tight binding of adsorbed albumin on fluoropolymers accounts for its success in blood-contacting applications.