Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2014)
    Biomaterial Interfaces Wednesday Sessions
       Session BI-WeM

Paper BI-WeM2
Self-Assembly of Macroscopic RNA Membrane

Wednesday, December 10, 2014, 8:20 am, Room Milo

Session: Biomaterials, Interfaces, and Cells
Presenter: Jong Bum Lee, University of Seoul, South Korea
Authors: Y. Park, University of Seoul, South Korea
H. Kim, University of Seoul, South Korea
J.B. Lee, University of Seoul, South Korea
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DNA and RNA have gained attention as powerful materials for bio-nanotechnology. Although, a variety of DNA structures have been developed, structures based on RNA are extremely rare. Here, we developed the robust and free-standing RNA membrane using an enzymatic synthetic method. This macroscopic RNA structure was fabricated by following two steps, complementary rolling circle transcription (cRCT) and evaporation-induced self-assembly (EISA). In addition, properties of the membrane can be controlled by adjusting base-pairing of RNA strands and the concentration of template circular DNA. In this research, we fabricated three types of RNA membranes and used these membranes for controlled drug release systems.