| AVS 64th International Symposium & Exhibition | |
| Biomaterial Interfaces Division | Tuesday Sessions |
| Session BI-TuP |
| Session: | Biomaterial Interfaces Poster Session with Flash presentations |
| Presenter: | Kayla Marquis, University of Maine |
| Authors: | K. Marquis, University of Maine A. Webber, University of Maine C. Howell, University of Maine |
| Correspondent: | Click to Email |
Nearly all methods that deliver bioactive compounds to the surface of a substrate rely on application from above or fail over time due to depletion of compounds. Here we explore the use of natural vascular channels embedded within polymeric matrices to allow for continuous, targeted, low concentration delivery of bioactive compounds to the surface from below. To achieve this, networks of empty 3D printed vascular channels are continuously filled with bioactive compounds. The compounds flow through the vascular network and diffuse through the polymer, eventually reaching the substrate surface of the matrix. By varying the locations and depths of these vascular channels we demonstrate that the amount of material and duration over which it is delivered to the surface can be controlled. The ability to control the diffusion of compounds both spatially and temporally is key in developing assays that test the effects of chemical gradients on various systems at both the cellular and organismal levels. This approach may prove useful in applications such as toxicity and wound healing assessment and targeted antifouling surfaces.