| AVS 64th International Symposium & Exhibition | |
| Biomaterial Interfaces Division | Thursday Sessions |
| Session BI+AS+SA-ThM |
| Session: | Characterisation of Biological and Biomaterial Surfaces |
| Presenter: | Lara Gamble, University of Washington |
| Authors: | L.J. Gamble, University of Washington D.J. Graham, University of Washington |
| Correspondent: | Click to Email |
Imaging time-of-flight mass spectrometry (ToF-SIMS) can provide images of cells and tissues with chemical and molecular specificity. These chemically specific images could revolutionize our understanding of biological processes such as the role of changes in tumor metabolism affecting the response to chemotherapy is under scrutiny. Regions of interest (ROIs) of the tumor can be utilized to compare similar regions from different tissue samples. PCA analysis of ToF-SIMS image data reveals the differences in chemistries between the regions. These results help to identify links between the chemical composition within and around tumors and the changes of these tumors as a response to the treatment. However, often the presentation of ToF-SIMS results might not be in the best format to gain the interest of non-SIMS scientists. Different data processing and data presentation format from clinical trial tissue samples and other tissue samples analyzed with ToF-SIMS will be presented. Additional validation of data interpretation from different techniques will be discussed.