AVS 64th International Symposium & Exhibition
    2D Materials Focus Topic Tuesday Sessions
       Session 2D+BI+MN+SS-TuA

Invited Paper 2D+BI+MN+SS-TuA3
Nanopores in 2D Materials

Tuesday, October 31, 2017, 3:00 pm, Room 16

Session: Surface Chemistry, Functionalization, Bio and Sensor Applications
Presenter: Aleksandra Radenovic, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland
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Atomically thin nanopore membranes are considered to be a promising approach to achieve single base resolution with the ultimate aim of rapid and cheap DNA sequencing. Recently, we made advances in using nanopore platform for its integration with 2 D materials such as graphene or MoS2. Translocation of various types of DNA exhibits a signal amplitude that is five times higher than in the case of solid-state Si3N4 membranes and a SNR of more than 10. These features are highly desirable for event detection and we take advantage of them by showing the electric-field induced unfolding of a 48 kbp long DNA molecule within the nanopore which manifests itself in the quantization of the current drop. Although single nucleotide identification and DNA sequencing using biological pores have already been demonstrated their fragility, difficulties related to measuring pA-range ionic currents together with their dependence on biochemical reagents, make solid state nanopores an attractive alternative. In this talk I will address novel applications that address identification of single nucleotides but as well go beyond DNA sequencing. We use novel solid state nanopore platform based on atomically thin nanopore membranes in 2D materials such as graphene or molybdenum disulfide for DNA detection, sequencing, water desalination and osmotic power generation.