AVS 62nd International Symposium & Exhibition
    Nanometer-scale Science and Technology Tuesday Sessions
       Session NS-TuP

Paper NS-TuP19
Design and Development of a Microfluidic Device for the Synthesis of Bioconjugated Lipidpolymer Hybrid Nanoparticles

Tuesday, October 20, 2015, 6:30 pm, Room Hall 3

Session: Nanometer-scale Science and Technology Poster Session
Presenter: Eri Takami, San Jose State University
Correspondent: Click to Email
In recent years, lipid ­polymer hybrid nanoparticles have gain attention as an efficient drug delivery device to treat various diseases, including cardiovascular disease, tuberculosis, and cancer. To synthesize lipid­polymer hybrid nanoparticles in a simple, efficient manner, we designed and developed a microfluidic device that utilizes a three channel pathway and a mixer channel. We prepared the microfluidic wafer using soft lithography techniques; with a negative masked designed with AutoCAD, we exposed UV light onto photoresist on a silicone wafer to outline the channels of the device. We then molded the microfluidic device using polydimethlsiloxane (PDMS) as the primary material for the fluid flow channels. The PDMS mold of the device was bonded to glass using plasma bonding in a vacuum chamber. The prepared microfluidic device can be customized to synthesize nanoparticles of different size, different encapsulated drug, and different surface functionalization. The production of higher quality nanoparticles in an efficient manner using our microfluidics device can expedite the research and development process of drug delivering lipid polymer hybrid nanoparticles.