AVS 62nd International Symposium & Exhibition
    IPF on Mesoscale Science and Technology of Materials and Metamaterials Tuesday Sessions
       Session IPF+MS-TuA

Invited Paper IPF+MS-TuA3
XFEL Movies of Molecular Machines at Work

Tuesday, October 20, 2015, 3:00 pm, Room 210F

Session: Frontiers in Physics
Presenter: John Spence, Arizona State University
Correspondent: Click to Email
With about 1E12 coherent hard X-ray photons per shot of 10 fs duration at 120 Hz, the invention of the X-ray laser (XFEL) has provided many new research opportunities for stuctural biology, which I will review. Our first discovery, that these pulse are so brief that they outrun radiation damage, so that damage-free diffraction patterns at atomic resolution and femtosecond time resolution can be recorded to make movies of protein function, has proved immensely fruitful. Other advances in solution scattering, analysis of protein nano crystals, and imaging of single particles which cannot easily be crystallized, such as viruses, wll be also be reviewed. This work forms part of the activity of the NSF’s BioXFEL STC, a consortium of seven US campuses devoted to the use of XFELs for Biology. (http://www.bioxfel.org).