Invited Paper IPF+MS-MoA3
Biomimetic Material Approaches to Tissue Engineering, Regenerative Medicine, and Wound Healing
Monday, October 19, 2015, 3:00 pm, Room 210F
There is growing clinical need in wound healing, tissue engineering, and regenerative medicine for controlled release systems that encapsulate therapeutic compounds and provide sustained release in a site-specific manner. Biocompatible, biodegradable nanofibrous scaffolds with their morphological similarities to the natural extracellular matrix (ECM) in vivo, high surface area to volume ratio, and small interfibrous pore sizes hold great potential for this application. Loading dopants within an electrospun polymeric matrix allows for consistent entrapment throughout the nanofibers. Further, the high surface area to volume ratio of these matrices maximizes the interaction of the carrier with a surrounding medium. A critical parameter for achieving success in controlled release is controlled diffusion of molecules out of the electrospun scaffolds. The drug release characteristics of nanofibrous scaffolds rely on how well the drug is encapsulated inside the nanofibers. These characteristics are critically affected by fiber morphology.
In this presentation, Dr. Loboa will discuss approaches in her lab to elucidate and optimize biomimetic fibrous systems for wound healing, tissue engineering, and regenerative medicine applications. Focus will be placed on regeneration of skin and musculoskeletal tissues and approaches to wound care and tissue regeneration while combating multi-drug resistant bacteria.