| AVS 62nd International Symposium & Exhibition | |
| Biomaterial Interfaces | Monday Sessions |
| Session BI+AS-MoA |
| Session: | Characterization of Biological and Biomaterials Surfaces (2) |
| Presenter: | Lars Schmüser, Max Planck Institute for Polymer Research, Mainz, Germany |
| Authors: | L. Schmüser, Max Planck Institute for Polymer Research, Mainz, Germany M. Paven, Max Planck Institute for Polymer Research, Mainz, Germany N. Encinas, Max Planck Institute for Polymer Research, Mainz, Germany D.J. Graham, University of Washington D.G. Castner, University of Washington D. Vollmer, Max Planck Institute for Polymer Research, Mainz, Germany H.J. Butt, Max Planck Institute for Polymer Research, Mainz, Germany T. Weidner, Max Planck Institute for Polymer Research, Mainz, Germany |
| Correspondent: | Click to Email |
Super non-fouling surfaces resist protein adhesion and have a broad field of possible application like implant technology, drug delivery, blood compatible materials, biosensors and marine coatings. Non fouling properties can be fabricated by using liquid repelling surfaces, which minimize the contact area of water soluble particles with the non fouling surface. For a surface to be “amphiphobic” – to repel a range of liquids including oil and water – requires a micro to nanometer scale surface roughness in combination with a hydrophobic coating. Paven et al. (1) described the production of an amphiphobic surface with remarkably low production requirements. This surface is made of a glass slide, candle soot and 2 commercially available chemicals which are deposited via chemical vapor deposition. Soot deposition and chemical vapor deposition can be applied to a broad variety of substrate shapes, such as the inner wall of tubes. This makes the soot coating a promising tool for blood compatible material design for stents and tubing including applications such as dialysis. Here we present a protein adsorption study onto these amphiphobic surfaces made of candle soot. Since even nanograms per cm2 levels of protein on biomaterial surfaces can cause detrimental effects for patients, we employed surface sensitive spectroscopic methods, X-ray photoelectron spectroscopy (XPS) and time of flight secondary ion mass spectrometry (ToF-SIMS) to quantify protein adsorption. We did not detect any adsorbed proteins within a detection limit of better than 1 ng/cm² of adsorbed proteins, which demonstrates the super non-fouling property of soot-coated surfaces. Interestingly, the naturally amphiphobic cuticle (“skin”) of springtails – small ancient arthropods who live in soil – use an approach very similar to the artificial soot surfaces to achieve protein repellency: Nanometer roughness with hydrophobic coatings. We will discuss XPS, ToF-SIMS and fluorescence microscopy studies quantifying the amount of protein adsorbed onto these surfaces.
1. M. Paven et al., Super liquid-repellent gas membranes for carbon dioxide capture and heart–lung machines. Nat Commun4, (2013).