AVS 61st International Symposium & Exhibition
    Biomaterial Interfaces Monday Sessions
       Session BI+AS-MoM

Paper BI+AS-MoM10
Polydopamine Modification Using Small Molecule Thiols and Dithiols: Problems and Solutions for Creating Protein Resistant Coatings

Monday, November 10, 2014, 11:20 am, Room 317

Session: Biomolecules & Biomaterials Interfaces
Presenter: Marlon Walker, National Institute of Standards and Technology (NIST)
Authors: M. Walker, National Institute of Standards and Technology (NIST)
A. Vaish, National Institute of Standards and Technology (NIST)
D. Vanderah, National Institute of Standards and Technology (NIST)
Correspondent: Click to Email

Polydopamine (PDA) is emerging as an increasingly useful bio-inspired coating for surface modification. Generated by a condensation reaction of dopamine in aqueous media under alkaline conditions, it can be readily deposited on almost any surface, forming thin films of controllable thicknesses. One useful attribute of a PDA coating is that it can be placed on and further modified to exhibit desired properties not possible with the underlying substrate. We present results of functionalizing PDA-coated surfaces on substrates such as silicon with oligo (ethylene oxide) thiols and dithiols for non-specific protein adsorption resistance.