Invited Paper MN+AS+SS-MoM1
Enhancing Selectivity and Sensitivity of Microfabricated Sensors using Multi-Scale Interactions
Monday, October 28, 2013, 8:20 am, Room 102 A
Achieving selectivity and sensitivity simultaneously in microfabricated chemical sensors has been a longstanding challenge. Chemical selectivity based on immobilized chemoselective receptors on sensor surfaces fails to achieve speciation in complex environments due to the generality of molecular interactions. However, by incorporating functions which can provide orthogonal signals, it is possible to achieve selectivity, sensitivity, and fast regeneration in miniature sensors. Modulating the physical properties of the surface adsorbed target molecules provides multi-scale information which can be analyzed for molecular recognition. The physical patterning of the sensor surface increases the number of target molecules adsorbed on the surface which results in higher sensitivity. I will discuss recent advances in the integration of multimodal signal generation onto a single platform in microfabricated sensors in order to achieve selectivity, sensitivity, and fast regeneration.