Polymeric surfaces of varied composition have been created in high density microarray formats. These patterned surfaces have been used to study a number of biointerface processes such as stem cell differentiation, and bacterial adhesion. Scienion offers non-contact picoliter dispensing technology that enables the creation of such surfaces. The inert glass capillaries allow for the use of a wide range of chemical reagents. Precision positioning enables drop-on-drop dispensing and mixing. Image analysis of the substrates in turns makes it possible to accurately dispense the materials onto almost any surface. This presentation will cover how Scienion technology is implemented for the production of polymeric surfaces.