Invited Paper TF+EM+SS-ThA1
Organic Monolayers on Silicon-rich Substrates: Methods and Mechanisms

Thursday, November 3, 2011, 2:00 pm, Room 110

SAMs on silicon-containing substrates including silicon, silicon nitride and glass widely expand the applicability of such materials. The presentation will focus on 3 recent developments:

1) The surface modification of H-terminated Si has functioned as a stepping-stone for the construction of a wide-range of hybrid materials. Recent synthetic improvements and detailed mechanistic studies have shown how to optimally construct such modified substrates. These results will be presented in the light of further developments.

2) Silicon nitride can be modified by covalent SAM attachment to achieve chemically highly robust systems. Biofunctionalization thereof with oligosaccharides and antibodies provides novel diagnostic applications in terms of specific bacterial capture in combination with generally antifouling substrates when combined with lithographic structuring of the material. Proof-of-principle and remaining challenges will be demonstrated based on recent experimental progress.

3) A photochemical method we recently developed to modify glass (SiO2), and the application thereof within the field of modified glass microchannels will be shown, e.g. via the on-chip embedding of enzymatic cascade reactions using a combination of local SAM attachment and DNA-enzyme hybrids. Finally, generalizations to the modification of other oxidic surfaces will be provided.

Key references:

H. Zuilhof and co-workers, J. Am. Chem. Soc. 2011, 133, 4998–5008.

H. Zuilhof, J. C. M. Van Hest and co-workers Chemical Science 2011, 2, in press (DOI: 10.1039/C1SC00146A).

H. Zuilhof and co-workers, Angew Chem. 2011, 50, in press (DOI: 10.1002/anie.201100835).