Invited Paper BP-SuA7
AVS 2011 Biointerphases Lecture - Tissue Engineering and Surface Science: 2D to 3D, Dry to Wet, Dead to Living and the Challenges to the Instrumentation
Sunday, October 30, 2011, 5:00 pm, Room 108
The biointerface and related surface science ideas have had profound impact on biomaterials science since at least the 1960’s. In the 21st century there is much discussion of tissue engineering, clearly a “3-D” phenomenon. This talk will review some history of the biointerface, illustrate modern trends, and show how biointerface ideas can be applied to tissue engineering and 3-D scaffolds. Techniques such as electron spectroscopy for chemical analysis (ESCA) and secondary ion mass spectrometry (SIMS) will be featured. SIMS has proven to be powerful for cell identification in culture dishes and for the analysis of decellularized extracellular matrix scaffolds. SIMS also provides much information on synthetic scaffold materials. There are now profound challenges in interpretation of complex spectra and in gleaning useful, biomedically relevant information from complex data sets. Finally, this talk will discuss healing, biointegration and regeneration, particularly in the context of new scaffolds made by a sphere-templating process.