| AVS 56th International Symposium & Exhibition | |
| Biomaterial Interfaces | Tuesday Sessions |
| Session BI-TuA |
| Session: | Biofouling |
| Presenter: | B.G. Liedberg, Linköping University, Sweden |
| Correspondent: | Click to Email |
The present contribution describes a novel set of hydrogel coatings prepared by self-initiated photografting and photopolymerization (SIPGP). The method is based on UV free radical polymerization of methacrylate and acrylate monomers into 0-200 nm thick coatings on top of virtually any organic/polymeric substrate. The vast majority of the coatings are based on different mixtures of PEG containing methacrylates. These hydrogels display excellent protein rejecting properties in simple single component solutions and mixtures, as well as in serum and plasma [1]. Recent studies on platelet adsorption looks also were promising. The UV fabrication technology is also compatible with patterning on the micrometer length scale, thus providing an attractive platform for biochip development and microarraying [2]. The preparation of gradients is also discussed for tuning the physio/chemical properties of the hydrogel coatings [3]. A novel set of charged balanced hydrogel gradients have been prepared for studies of protein adsorption from protein mixtures and plasma with encouraging results [4]. Finally we describe an approach for array fabrication of nanobrushes/bushes on a pre-patterned template generated by Dip Pen Nanolithography (DPN).
1. A. Larsson, T. Ekblad, O. Andersson, B. Liedberg, Biomacromolecules, 8, 287-295 (2007).
2. A. Larsson, C-.X. Du, B. Liedberg, Biomacromolecules, 8, 3511 (2007).
3. A. Larsson, B. Liedberg, Langmuir, 23, 11319 (2007).
4. T. Ekblad, O. Andersson, F.-I. Tai, T. Ederth, B. Liedberg. Langmuir, 25, 3755 (2009).