AVS 55th International Symposium & Exhibition
    Nanometer-scale Science and Technology Tuesday Sessions
       Session NS+NC-TuA

Paper NS+NC-TuA4
Silicon Nanowire Resonators as Mass Sensors for a Specific Detection of Proteins

Tuesday, October 21, 2008, 2:40 pm, Room 311

Session: Nanowires and Nanosize Effects
Presenter: S. Evoy, University of Alberta, Canada
Authors: S. Evoy, University of Alberta, Canada
M. Belov, University of Alberta, Canada
V.A. Wright, University of Alberta, Canada
J.M. Buriak, University of Alberta, Canada
N. Quitoriano, Hewlett-Packard Laboratories
T. Kamins, Hewlett-Packard Laboratories
Correspondent: Click to Email

Silicon nanowire resonators have been proposed as highly-sensitive transducers for the detection of molecular systems. High-quality nanometer scale resonators grown by the chemical vapor deposition (CVD) offer a potent approach for the production of cantilevered nanowires. Nanowire resonators were laterally grown from the sides of silicon posts using a CVD metal-catalyzed process. The diameters and lengths of the structures ranged from 40 to 400 nanometers and from 2 to 20 micrometers, respectively. An optical interferometric method was used to determine the resonant frequencies and quality factors of these resonators. Resonant properties of these devices at various temperatures and pressures are discussed. Nanowire resonators (with diameters 100 nanometers and lengths 3.3 micrometers) were functionalized using a monolayer of mercaptopropyltrimethoxysilane as a linker, followed by a functionalization with biotin. The attached biotin molecules enabled the specific attachment and detection of streptavidin molecules. Shifts of resonant frequencies by hundreds of kHz were observed, corresponding to an added streptavidin mass ranging from 1 to 3 femtograms. This work was supported by Alberta Innovation and Science and by Hewlett-Packard Laboratories.