| AVS 55th International Symposium & Exhibition | |
| Biomaterial Interfaces | Tuesday Sessions |
| Session BI-TuP |
| Session: | Biomaterials Interfaces Poster Session with Focus on Cells and Proteins at Interfaces |
| Presenter: | S. Berner, Institut Straumann AG, Switzerland |
| Authors: | A. Molenberg, Institut Straumann AG, Switzerland S. Berner, Institut Straumann AG, Switzerland F. Schwarz, Heinrich Heine University, Germany M. Herten, Heinrich Heine University, Germany M. de Wild, Institut Straumann AG, Switzerland M. Wieland, Institut Straumann AG, Switzerland |
| Correspondent: | Click to Email |
The performance of bone-related implants is strongly connected with the properties of the implant surface. Particularly surface topography and chemistry both influence initial wettability and peri-implant bone apposition of implants. Sandblasted and acid etched (SLA) titanium surfaces are initially hydrophobic due to microstructuring and adsorption of hydrocarbons and carbonates. The purpose of this study was to investigate initial hydrophilicity and to examine tissue reactions to a newly developed chemically modified implant surface called SLActive. Implantation of SLActive and SLA implants was performed bilaterally in dogs. The animals were sacrificed after a healing period of 1, 4, 7 and 14 days, respectively. Peri-implant tissue reactions were assessed in nondecalcified tissue sections using conventional histology (Toluidine blue-TB and Masson Goldner Trichrome stain-MG) and immuno¬histochemistry using monoclonal antibodies to transglutaminase II (TG) (angiogenesis) and osteocalcin (OC) (mineralization). Bone density (BD) and bone to implant contact (BIC) were assessed histomorphometrically. Immunohistochemical staining for TG revealed a direct correlation between angiogenesis and new bone formation, which was clearly identifiable after 7 days by means of increasing BD, BIC and OC values. After 14 days, SLActive surfaces seemed to be surrounded by a firmly attached mature, parallel-fibered woven bone. The study clearly reveals an enhanced bone formation for the hydrophilic SLActive surface and thus a reduced healing time.