| AVS 55th International Symposium & Exhibition | |
| Biomaterial Interfaces | Thursday Sessions |
| Session BI-ThP |
| Session: | Biomaterial Interfaces Poster Session with Focus on Engineered Bio-Interfaces and Sensors |
| Presenter: | H.C. Lo, National Chiao-Tung University, Taiwan |
| Authors: | H.C. Lo, National Chiao-Tung University, Taiwan H.I. Hsiung, National Taiwan University Sv Chattopadhyay, National Yang-Ming University, Taiwan C.F. Chen, Ming-Dao University, Taiwan J. Leu, National Chiao-Tung University, Taiwan K.H. Chen, Academia Sinica, Taiwan L.C. Chen, National Taiwan University |
| Correspondent: | Click to Email |
Optical sensing of adenine and thymine nucleic acid species have been achieved at the femtomolar level using self assembled gold and silver nanoparticles coated silicon nanotips (SiNTs) arrays. The use of sub-10 nm metal particulates with optimum density and inter-particle distance ensures such high levels of sensitivity in surface enhanced Raman scattering experiments. In this work wafer-scale silicon nanotip arrays were fabricated using a patented self masked dry etching technique to provide an excellent platform for the metal self assembly. This structure consists of the SiNTs with apex and bottom diameter of ~ 1 nm and ~ 100 nm, respectively, length of ~ 1000 nm and density of 1011/cm2. The high density of gold and silver nanoparticles and short inter-particle distance enabled the bio-immobilization and amplification of the Raman signals of adsorbed molecules, allowing identification of minute amount of the adsorbed molecules with chemical specificity. The high sensitivity of surface enhanced Raman scattering can be maintained over a considerable period of time. The vibrational Raman signals of immobilized species can be detected even after four months of conservation. The straightforward, binder-less, stable and room temperature bio-molecular detection underlines the effectiveness of surface enhanced Raman scattering vis-á-vis fluorescence.