AVS 55th International Symposium & Exhibition | |
Biomaterial Interfaces | Thursday Sessions |
Session BI+NC-ThM |
Session: | Engineering Biointerfaces |
Presenter: | A.N. Parikh, University of California, Davis |
Authors: | A.N. Parikh, University of California, Davis B. Sanii, University of California, Davis A.M. Smith, University of California, Davis M. Howland, University of California, Davis A.M.A.M. Brozell, University of California, Davis |
Correspondent: | Click to Email |
Interfacial organization of lipids and amphiphiles into a discrete number of molecular layers provides,arguably, one of the most pristine experimental realizations of elf-organized, two-dimensional systems. it provides an experimental test-bed for the study of a rich variety of interface-dominated processes, including surface melting, low-dimensional phase transitions, surface dynamics, and phase coexistence and separation. This talk will present recent experimental evidence from our laboratories which highlight the importance of substrate structure (e.g., topography, charge, and surface energies) in engineering the physical properties, namely curvature, morphology, and lateral dynamics, in supported lipid bilayers. Applications of such engineered surfaces in examining the dependence of membrane phase separation and phase transition on bilayer curvature and morphology will be discussed.