AVS 54th International Symposium | |
Nanomanufacturing Topical Conference | Wednesday Sessions |
Session NM-WeM |
Session: | Nanomanufacturing for Information Technologies |
Presenter: | L.J. Whitman, Naval Research Laboratory |
Correspondent: | Click to Email |
On December 5, 1995 David Baselt, at the time a postdoctoral researcher at NRL working on a cantilever-based biosensor using magnetic particle labels, wrote in his lab notebook, "Did some reading on magnetoresistive sensors. It may be possible to use these rather than piezolevers to detect magnetic particles." Over the past dozen years, a dynamic team of researchers at NRL has developed this idea into the compact Bead Array Sensor System (cBASS®), a prototype biosensor system that integrates a suite of patented and patent-pending technologies for magnetic labeling and biomolecular detection, biomolecular assay methods, surface chemistry, and microfluidics.1-9 The current system is capable of multiplexed detection of biomolecules at attomolar concentrations in complex matrices in <20 min with little or no sample preparation. The technology has been licensed for a variety of applications, including food and water testing, environmental analysis, veterinary diagnostics, and biodefense. I will describe the development history of this project, the challenges of moving an idea from concept to advanced development within a government laboratory, and some of the lessons learned along the way.
1Baselt et al., Biosens. Bioelectron. 13, 731 (1998).
2U.S. Patent 5,981,297.
3Edelstein et al., Biosens. Bioelectron. 14, 805 (2000).
4Tamanaha et al., J. Micromech. Microeng. 12, N7 (2002).
5Sheehan et al., Biosens. Bioelectron. 18, 1455 (2003)
6Rife et al., Sensors Actuat. A 107, 209 (2003).
7Sheehan and Whitman, Nano Lett. 5, 803 (2005).
8Stine et al., Langmuir 23, 4400 (2007).
9Mulvaney et al., Biosens. Bioelectron., in press.