| AVS 54th International Symposium | |
| Biomaterial Interfaces | Tuesday Sessions |
| Session BI-TuP |
| Session: | Biomaterials Interfaces Poster Session |
| Presenter: | R. Foerch, Max-Planck-Institut for Polymer Research, Germany |
| Authors: | R. Foerch, Max-Planck-Institut for Polymer Research, Germany S. Brueninghoff, Max-Planck-Institut for Polymer Research, Germany E.-K. Sinner, Max-Planck-Institut for Polymer Research, Germany W. Knoll, Max-Planck-Institut for Polymer Research, Germany R. Berger, Max-Planck-Institut for Polymer Research, Germany |
| Correspondent: | Click to Email |
The controlled adhesion of biomolecules on surfaces has become a major topic of interest in biomaterial surface design. The interest in this has been triggered by a broad range of biomaterial applications. For example, those that rely on proteins and cells immobilized on solid surfaces for the development of new implant materials and tissue regeneration. It is generally accepted that both the surface morphology and the surface chemistry need to be in concert to ensure optimum conditions for biomaterial adhesion. However, the surface interactions are very complex and are not completely understood. Further, there are only very few analytical tools available that deliver reliable, real time insights into the biomaterial/ surface interactions. We present recent results in which plasma polymerization techniques have been used to prepare “model” surfaces that can be conditioned towards the adhesion of a particular mammalian cell line (P19 progenitor cells). Techniques such as Surface Plasmon Resonance (SPR), Micro-Cantilever Sensor technology (MCS) and standard optical microscopy have been used to study in real time the adsorption of proteins and P19 cells on such surfaces. Correlations to the chemical environment at the interface are made.