| Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2014) | |
| Nanomaterials | Tuesday Sessions |
| Session NM-TuP |
| Session: | Nanomaterials Poster Session |
| Presenter: | Xia Zhang, Northeastern University, China |
| Correspondent: | Click to Email |
The nanomaterials have been widely applied in the biomedical area, which play important role in the disease diagnosis and treatment, tissue repair and proteins separation. Nano-TiO2, as a biologically inert material, shows good biocompatibility and bonding biological activity of the protein. In addition, the surface modification of TiO2 can be achieved by the surface bonding between its surface hydroxyl groups and organic molecules. Furthermore, the research on the selective adsorption of proteins on the functionalized nanomaterials has important theoretical significance and application value in the field of protein separation.
In this work, TiO2 nanoparticles were prepared by improved hydrothermal method, and then some organic molecule, such as silane KH560 and oleic acid were used to modify the TiO2 nanoparticles. Some means, such as TEM, XRD, TG-DSC, and FT-IR were used to character the functionalized TiO2 nanoparticles. The results showed that the organic molecules were successfully combined on the surface of TiO2 nanoparticles via chemical bond and physical weak interaction.
These functionalized TiO2 nanoparticles were used in the adsorption experiments of bovine hemoglobin (BHb) and bovine serum albumin (BSA). The effects of different conditions on the adsorption capacity were studied systematically, and the optimum adsorption conditions were determined. Compared with the original nano-TiO2, after surface modification, the functionalized TiO2 nanoparticles showed selective adsorption activity toward BHb. For example, under optimum conditions (c0 (BHb or BSA) = 150 mg/L, m (TiO2) =0.8 mg/mL, t = 80 min.), for the pure TiO2 nanoparticles, the adsorption capacity of BHb and BSA was 70.6 mg/g and 40 mg/g respectively. Meanwhile, for the KH560 modified TiO2, the maximum adsorption capacity of BHb was 122.8 mg/g and the adsorption of BSA was almost 0.