| Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2014) | |
| Nanomaterials | Monday Sessions |
| Session NM-MoE |
| Session: | Nanomaterials Characterization & Reactivity I |
| Presenter: | Bunlaporn Thumrongthanyaluk, International School of Engineering, Chulalongkorn University, Thailand |
| Authors: | W. Srituravanich, Department of Mechanical Engineering, Chulalongkorn University, Thailand B. Thumrongthanyaluk, International School of Engineering, Chulalongkorn University, Thailand |
| Correspondent: | Click to Email |
Titanium dioxide nanotubes (TiO2 NTs) have attracted significant attention in biomedical applications due to their biocompatibility and photocatalytic properties. Such a nanomaterial can be coupled with near-infrared irradiation to heat bio-molecules such as cancer cells causing them to death so-called cancer photothermal therapy. In this work, we proposed a novel method to fabricate isolated TiO2 NTs and utilized them as a therapeutic agent in cancer photothermal therapy. TiO2 NTs were synthesized by anodization of titanium electrode using diethylene glycol (DEG) +2 vol% HF as electrolyte. TiO2 NTs were then isolated from Ti substrate by sonication in isopropanol (IPA) for 20 mins. The hepatic cancerous cells (HepG2) were treated with different concentrations of isolated TiO2 NTs; 0, 6.25, 12.5 and 25 mg/ml under three exposure conditions; dark (no irradiation), UV and Near-Infrared (NIR) irradiation. After the treatment, in vitro cell experiment was performed to measure the viability of the cells. According to the results, the viability of cells under NIR irradiation dropped with the increment of the concentration of TiO2 NTs. At the concentration of 25 mg/ml the viability was reduced by 31%. Thus, isolated TiO2 NTs shows promising results for cancer photothermal therapy.